Catalogue d'objets introuvables - Tomes 1 et 2 by Jacques Carelman

By Jacques Carelman

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Generate_Screen • Project Title: LUNG CANCER PREVENTION BY COX2 AND 5LOX INHIBITORS Principal Investigator & Institution: Lotan, Reuben; Professor; University of Texas Md Anderson Can Ctr Cancer Center Houston, Tx 77030 Timing: Fiscal Year 2002 Studies 25 Summary: (provided by applicant): We propose to test the hypothesis that inhibitors of COX-2 and 5-LOX and certain retinoids or their combinations can be effective chemopreventive agents against lung cancer by inducing apoptosis. The objectives of this project are: to identify potentially effective agents for lung cancer prevention among inhibitors of COX-2, 5-LOX, and retinoids or a combination of these agents using in vitro and in vivo systems and to provide insight into their mechanism of action on normal, premalignant, and malignant lung epithelial cells.

3) Finally we will examine the retention of FLT in patients undergoing therapy that combines targeted agents; inhibitors of epidermal growth factor receptor 24 Celecoxib gefitinib (Iressa, ZD1839) and cyclooxygenase 2 (celecoxib). We seek to determine if PET can provide an early measure of efficacy before conducting large phase III trials. In summary, our proposal seeks to develop FLT imaging for use in the evaluation of lung cancer treatment. Our ultimate goal is to demonstrate that this approach is useful in evaluating both experimental and routine clinical treatment.

Most of those deaths are due to invasive transitional cell carcinoma (TCC) that has metastasized and is resistant to chemotherapy. Our long range goal is to Studies 31 develop more effective treatment for invasive TCC. Cyclooxygenase (Cox) inhibitors have induced apoptosis and caused regression of invasive TCC in animal studies. The antitumor activity of Cox inhibitors is thought to be due, at least in part, to inhibition of Cox and the resulting decrease in Cox products (prostaglandins and thromboxanes).

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